Adenine Deoxy Nucleoside
Also known as: Adenosine Adenyldeoxyriboside Deoxyadenosine Desoxyadenosine Adenine Deoxyribonucleoside Adenine Deoxyribose Adenine Nucleoside Adenine Riboside
Brand names: ADENOCARD ADENOCOR
Therapeutic Indications
Adenine Deoxy Nucleoside is indicated for:
Paroxysmal supraventricular tachycardias, Wolff-Parkinson-White Syndrome
Irrespective of gender only Children (1 year - 12 years old) , Adolescents (12 years - 18 years old)
Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome).
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - first bolus of 0.1 mg/kg, increments of 0.1 mg/kg
Paroxysmal supraventricular tachycardias, Wolff-Parkinson-White Syndrome
Irrespective of gender only Adults (18 years old or older)
Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome).
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - Initial dose 3mg, Second dose 6mg, Third dose 12mg
Contraindications
Active ingredient Adenine Deoxy Nucleoside is contraindicated in the following cases:
Dipyridamole
No gender/age discrimination
Dipyridamole inhibits adenosine cellular uptake and metabolism, and potentiates the action of adenosine. In one study dipyridamole was shown to produce a 4 fold increase in adenosine actions. Asystole has been reported following concomitant administration.
It is therefore suggested that adenosine should not be administered to patients receiving dipyridamole; if use of adenosine is essential, dipyridamole should be stopped 24 hours before hand, or the dose of adenosine should be greatly reduced.
Long QT syndrome
No gender/age discrimination
Adenosine is contraindicated for patients presenting long QT syndrome.
Chronic obstructive lung disease, bronchospasm, asthma
No gender/age discrimination
Adenosine is contraindicated for patients presenting chronic obstructive lung disease with evidence of bronchospasm (e.g. asthma bronchiale).
Second or third degree Atrio-Ventricular (AV) block
No gender/age discrimination
Adenosine is contraindicated for patients presenting second or third degree Atrio-Ventricular (AV) block (except in patients with a functioning artificial pacemaker).
Hypersensitivity to adenosine
No gender/age discrimination
Sick sinus syndrome
No gender/age discrimination
Adenosine is contraindicated for patients presenting sick sinus syndrome (except in patients with a functioning artificial pacemaker).
Decompensated states of heart failure
No gender/age discrimination
Adenosine is contraindicated for patients presenting decompensated states of heart failure.
Severe hypotension
No gender/age discrimination
Adenosine is contraindicated for patients presenting severe hypotension.