Adenine Deoxy Nucleoside

Also known as: Adenine Deoxyribonucleoside Adenine Deoxyribose Adenine Nucleoside Adenine Riboside Adenosine Adenyldeoxyriboside Deoxyadenosine Desoxyadenosine

Therapeutic indications

Adenine Deoxy Nucleoside is indicated for:

Paroxysmal supraventricular tachycardias, Wolff-Parkinson-White Syndrome

Irrespective of gender only Children (1 year - 12 years old) , Adolescents (12 years - 18 years old)

Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome).

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Intravenous - first bolus of 0.1 mg/kg, increments of 0.1 mg/kg

Paroxysmal supraventricular tachycardias, Wolff-Parkinson-White Syndrome

Irrespective of gender only Adults (18 years old or older)

Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome).

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Intravenous - Initial dose 3mg, Second dose 6mg, Third dose 12mg

Contraindications

Active ingredient Adenine Deoxy Nucleoside is contraindicated in the following cases:

Dipyridamole

Dipyridamole inhibits adenosine cellular uptake and metabolism, and potentiates the action of adenosine. In one study dipyridamole was shown to produce a 4 fold increase in adenosine actions. Asystole has been reported following concomitant administration.

It is therefore suggested that adenosine should not be administered to patients receiving dipyridamole; if use of adenosine is essential, dipyridamole should be stopped 24 hours before hand, or the dose of adenosine should be greatly reduced.

Chronic obstructive lung disease, bronchospasm, asthma

Adenosine is contraindicated for patients presenting chronic obstructive lung disease with evidence of bronchospasm (e.g. asthma bronchiale).

Second or third degree Atrio-Ventricular (AV) block

Adenosine is contraindicated for patients presenting second or third degree Atrio-Ventricular (AV) block (except in patients with a functioning artificial pacemaker).

Hypersensitivity to adenosine

Sick sinus syndrome

Adenosine is contraindicated for patients presenting sick sinus syndrome (except in patients with a functioning artificial pacemaker).

Decompensated states of heart failure

Adenosine is contraindicated for patients presenting decompensated states of heart failure.

Severe hypotension

Adenosine is contraindicated for patients presenting severe hypotension.

Long QT syndrome

Adenosine is contraindicated for patients presenting long QT syndrome.