Aficamten

Chemical formula: C₁₈H₁₉N₅O₂  Molecular mass: 337.154 g/mol  PubChem compound: 139331495

Active ingredient description

Aficamten is an allosteric and reversible inhibitor of cardiac myosin motor activity. Aficamten reduces the force generated by myosin at the cardiac sarcomere, which contributes to the pathophysiology of HCM. In patients with HCM, myosin inhibition with aficamten reduces cardiac contractility and left ventricular outflow tract (LVOT) obstruction.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 MYQORZO Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

DrugBank Drug: DB18490
KEGG Drug: D12253
PubChem Compound: 139331495
UNII Identifier: B1I77MH6K1
AFICAMTEN

Medicines

Aficamten is an active ingredient of these brands:

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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