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Aflibercept

Description

Aflibercept, also known as VEGF TRAP in the scientific literature, is a recombinant fusion protein consisting of VEGF-binding portions from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of the human IgG1. Aflibercept blocks the activation of VEGF receptors and the proliferation of endothelial cells, thereby inhibiting the growth of new vessels that supply tumours with oxygen and nutrients.

ATC Classification

Code
Title
Category
L01XX44
Aflibercept
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents
S01LA05
Aflibercept
S Sensory organs → S01 Ophthalmologicals → S01L Ocular vascular disorder agents → S01LA Antineovascularisation agents

Trade names

Trade name
Countries

Australia Austria Canada Cyprus France

Austria Cyprus France Netherlands Singapore

Product Monographs

Monograph
Type
Country
ZALTRAP Concentrate for solution for infusion
MPI, EU: SmPC
EYLEA Solution for injection
MPI, EU: SmPC