Aflibercept

Chemical formula: C₄₃₁₈H₆₇₈₈N₁₁₆₄O₁₃₀₄S₃₂ Molecular mass: 115,000 g/mol

Therapeutic indications

Aflibercept is indicated for:

Metastatic colorectal cancer (MCRC)

Population group: only adults (18 years old or older)

Aflibercept in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) chemotherapy is indicated in adults with metastatic colorectal cancer (MCRC) that is resistant to or has progressed after an oxaliplatin-containing regimen.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

4 mg/kg once every 2 weeks

Neovascular (wet) age-related macular degeneration (AMD)

Population group: only adults (18 years old or older)

Exudative age-related macular degeneration

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 mg once every month

Visual impairment due to macular oedema secondary to retinal vein occlusion (branch RVO or central RVO)

Population group: only adults (18 years old or older)

Thrombosis of retinal vein and additionally Macular retinal edema

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 mg once every month

Visual impairment due to diabetic macular oedema (DME)

Population group: only adults (18 years old or older)

Diabetic macular edema

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 mg once every month

Visual impairment due to myopic choroidal neovascularisation (myopic CNV)

Population group: only adults (18 years old or older)

mCNV - myopic choroidal neovascularisation

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 mg once every month

Contraindications

Aflibercept is contraindicated in the following cases:

Ocular, periocular, intraocular inflammation or infection

Ophthalmitis

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