Alemtuzumab

Chemical formula: C₆₄₆₈H₁₀₀₆₆N₁₇₃₂O₂₀₀₅S₄₀  Molecular mass: 145,453.8 g/mol 

Active ingredient description

Alemtuzumab is a genetically engineered humanised IgG1 kappa monoclonal antibody specific for a 21-28 kD lymphocyte cell surface glycoprotein (CD52) expressed primarily on the surface of normal and malignant peripheral blood B and T cell lymphocytes. Alemtuzumab acts through antibody-dependent cellular cytolysis and complement-mediated lysis following cell surface binding to CD52, a cell surface antigen present at high levels on T (CD3+) and B (CD19+) lymphocytes, and at lower levels on natural killer cells, monocytes, and macrophages.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AG06 Alemtuzumab L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AG Monoclonal antibodies
Discover more medicines within L04AG06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LEMTRADA Concentrate for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 216503-57-0
DrugBank Drug: DB00087
RxNorm Ingredient: 117055
SNOMED-CT Concept: 129472003
Alemtuzumab (substance)
UNII Identifier: 3A189DH42V
ALEMTUZUMAB

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