Chemical formula: C₆₄₆₈H₁₀₀₆₆N₁₇₃₂O₂₀₀₅S₄₀  Molecular mass: 145,453.8 g/mol 

Therapeutic indications

Alemtuzumab is indicated for:

Relapsing remitting multiple sclerosis (RRMS)

Population group: only adults (18 years old or older)

Alemtuzumab is indicated as a single disease modifying therapy in adults with highly active relapsing remitting multiple sclerosis (RRMS) for the following patient groups:

  • Patients with highly active disease despite a full and adequate course of treatment with at least one disease modifying therapy (DMT) or
  • Patients with rapidly evolving severe relapsing remitting multiple sclerosis defined by 2 or more disabling relapses in one year, and with 1 or more Gadolinium enhancing lesions on brain MRI or a significant increase in T2 lesion load as compared to a previous recent MRI.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Alemtuzumab is contraindicated in the following cases:

Human Immunodeficiency Virus (HIV) infection

Human immunodeficiency virus infection



Severe active infection

Infectious disease





Arterial dissection of the cervicocephalic arteries

Dissection of cervicocerebral artery


at least one of
CVA - Cerebrovascular accident

Angina pectoris, myocardial infarction

at least one of
H/O: angina pectoris
Myocardial infarction
Past history of myocardial infarction

Coagulopathy, anti-platelets, anti-coagulants

at least one of
Blood coagulation disorder
Antithrombotic agents

Concomitant autoimmune diseases

Autoimmune disease and additionally not Relapsing remitting multiple sclerosis

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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