Also known as: α1-antitrypsin Serpin family A member 1 Alpha1 proteinase inhibitor A1PI A1AT
Human alpha1-proteinase inhibitor is understood to be the primary anti-protease in the lower respiratory tract, where it inhibits neutrophil elastase (NE). Normal healthy individuals produce sufficient alpha1-proteinase inhibitor to control the NE produced by activated neutrophils and are thus able to prevent inappropriate proteolysis of lung tissue by NE.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Alfa1 antitrypsin is the active ingredient of these drugs:
France
United States
Spain
Austria France Ireland Netherlands
Brazil Canada United States
Finland Spain
Austria Cyprus Estonia France Ireland
Brazil
Brazil New Zealand
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):