Alfa1 antitrypsin

Also known as: α1-antitrypsin Serpin family A member 1 Alpha1 proteinase inhibitor A1PI A1AT

Active ingredient description

Human alpha1-proteinase inhibitor is understood to be the primary anti-protease in the lower respiratory tract, where it inhibits neutrophil elastase (NE). Normal healthy individuals produce sufficient alpha1-proteinase inhibitor to control the NE produced by activated neutrophils and are thus able to prevent inappropriate proteolysis of lung tissue by NE.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Alfa1 antitrypsin
B Blood and blood forming organs → B02 Antihemorrhagics → B02A Antifibrinolytics → B02AB Proteinase inhibitors
Discover more medicines within B02AB02

Medicines

Alfa1 antitrypsin is the active ingredient of these drugs:

Drug
Countries

France

United States

Spain

Austria France Ireland Netherlands

Brazil Canada United States

Finland Spain

Austria Cyprus Estonia France Ireland

Brazil

Brazil New Zealand

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)

External identifiers

CAS Substance: 9041-92-3
DrugBank Drug: DB00058
RxNorm Ingredient: 535
SNOMED-CT Concept: 14767006
Human alpha1 proteinase inhibitor (substance)
UNII Identifier: F43I396OIS
.ALPHA.1-PROTEINASE INHIBITOR HUMAN