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ATC Group: B02AB Proteinase inhibitors

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Proteinase inhibitors

Hierarchical Position

Level
Code
Title
4
B02AB
Proteinase inhibitors

Contents

Code
Title
B02AB01
B02AB03
B02AB04
B02AB05

Active Ingredients

Chemical substance
Description

Human alpha1-proteinase inhibitor is understood to be the primary anti-protease in the lower respiratory tract, where it inhibits neutrophil elastase (NE). Normal healthy individuals produce sufficient alpha1-proteinase inhibitor to control the NE produced by activated neutrophils and are thus able to prevent inappropriate proteolysis of lung tissue by NE.

Aprotinin is a broad spectrum protease inhibitor which has antifibrinolytic properties. By forming reversible stoichiometric enzyme-inhibitor complexes, aprotinin acts as an inhibitor of human trypsin, plasmin, plasma kallikrein and tissue kallikrein, thus inhibiting fibrinolysis.

Monographs

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