Chemical formula: C₂₈₄H₄₃₂N₈₄O₇₉S₇  Molecular mass: 6,510.051 g/mol  PubChem compound: 22833874

Active ingredient description

Aprotinin is a broad spectrum protease inhibitor which has antifibrinolytic properties. By forming reversible stoichiometric enzyme-inhibitor complexes, aprotinin acts as an inhibitor of human trypsin, plasmin, plasma kallikrein and tissue kallikrein, thus inhibiting fibrinolysis.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B02AB01 Aprotinin B Blood and blood forming organs → B02 Antihemorrhagics → B02A Antifibrinolytics → B02AB Proteinase inhibitors
Discover more medicines within B02AB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
APROTININ Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

External identifiers

CAS Substance: 9004-04-0
CAS Substance: 9087-70-1
DrugBank Drug: DB06692
KEGG Drug: D02971
PubChem Compound: 22833874
RxNorm Ingredient: 1056
SNOMED-CT Concept: 386961008
Aprotinin (substance)
UNII Identifier: 04XPW8C0FL


Aprotinin is an active ingredient of these brands:

United States (US)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

  • (combination) BERIPLAST-P as Aprotinin from bovine lung

Malta (MT)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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