Alfacalcidol
Also known as: 1-hydroxycholecalciferol 1alpha-hydroxycholecalciferol 1alpha-hydroxyvitamin D3 Alphacalcidol
Therapeutic Indications
Alfacalcidol is indicated for:
Renal osteodystrophy, hypoparathyroidism, rickets, osteomalacia
Irrespective of gender only Elderly (65 years old or older)
Alfacalcidol is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function.
The main indications are:
- Renal osteodystrophy
- Hypoparathyroidism
- Nutritional and malabsorptive rickets and osteomalacia
- Pseudo-deficiency (D-dependent) rickets and osteomalacia
- Hypophosphataemic vitamin D resistant rickets and osteomalacia
- Hyperparathyroidism (with bone disease)
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Oral - 0.5 microgram/day
Renal osteodystrophy, hypoparathyroidism, rickets, osteomalacia
Irrespective of gender only Infants (40 days - 1 year old) , Children (1 year - 12 years old)
Alfacalcidol is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function.
The main indications are:
- Renal osteodystrophy
- Hypoparathyroidism
- Nutritional and malabsorptive rickets and osteomalacia
- Pseudo-deficiency (D-dependent) rickets and osteomalacia
- Hypophosphataemic vitamin D resistant rickets and osteomalacia
- Hyperparathyroidism (with bone disease)
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Oral - 0.05 microgram/kg/day
Treatment 2: Intravenous - 0.05 mcg / kg / day
Renal osteodystrophy, hypoparathyroidism, rickets, osteomalacia
Irrespective of gender only Newborns (0 - 40 days old)
Alfacalcidol is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function.
The main indications are:
- Renal osteodystrophy
- Hypoparathyroidism
- Nutritional and malabsorptive rickets and osteomalacia
- Pseudo-deficiency (D-dependent) rickets and osteomalacia
- Hypophosphataemic vitamin D resistant rickets and osteomalacia
- Hyperparathyroidism (with bone disease)
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Oral - 0.05 - 0.1 microgram/kg/day
Treatment 2: Intravenous - 0.05-0.1 mcg / kg / day
Renal osteodystrophy, hypoparathyroidism, rickets, osteomalacia
Irrespective of gender only Adolescents (12 years - 18 years old) , Adults (18 - 65 years old)
Alfacalcidol is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function.
The main indications are:
- Renal osteodystrophy
- Hypoparathyroidism
- Nutritional and malabsorptive rickets and osteomalacia
- Pseudo-deficiency (D-dependent) rickets and osteomalacia
- Hypophosphataemic vitamin D resistant rickets and osteomalacia
- Hyperparathyroidism (with bone disease)
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Oral - 1 microgram/day
Treatment 2: Intravenous - 1 microgram/day
Contraindications
Active ingredient Alfacalcidol is contraindicated in the following cases:
Pregnancy
No gender/age discrimination
There is a limited amount of data from the use of alfacalcidol in pregnant women. Studies in animals have shown reproductive toxicity at high doses. Therefore, alfacalcidol is not recommended during pregnancy and in women of child-bearing potential not using contraception.
Hypercalcaemia
No gender/age discrimination
Alfacalcidol is condraindicated in hypercalcaemia.