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Alirocumab

PRALUENT

Therapeutic Indications

Alirocumab is indicated for:

Primary heterozygous familial hypercholesterolaemia, primary non-familial hypercholesterolaemia, mixed dyslipidaemia

Irrespective of gender only Adults (18 years old or older)

Alirocumab is indicated in adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia, as an adjunct to diet:

  • in combination with a statin or statin with other lipid lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin or,
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.

The effect of alirocumab on cardiovascular morbidity and mortality has not yet been determined.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Subcutaneous - 75-150 mg once every 2 weeks

Treatment 2: Subcutaneous - 150-300 mg once every 4 weeks

Contraindications

Active ingredient Alirocumab is contraindicated in the following cases: