Alprostadil
Brand names: ALPRESTIL ALPROSTAPINT CAVERJECT EDEX MINPROG MUSE PRIDAX PROSTAVASIN PROSTIN VR VITAROS
Therapeutic Indications
Alprostadil is indicated for:
Erectile dysfunction
Men inly, only Adults (18 years old or older)
Alprostadil is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Alprostadil may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intracavernous - 1.25-40 μg
Treatment 2: Urethral - 125-1000 μg
Temporary maintenance of patency of the ductus arteriosus until corrective or palliative surgery
Irrespective of gender only Newborns (0 - 40 days old)
Alprostadil is indicated to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in infants who have congenital defects and who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atresia, tetralogy of Fallot, interruption of the aortic arch, co-arctation of the aorta, aortic stenosis, aortic atresia, mitral atresia, or transposition of the great vessels with or without other defects.
For this indication, the medical literature mentions below treatments (click for details):
Treatment 1: Intravenous - 0.05-0.1 μg/kg/min
Contraindications
Active ingredient Alprostadil is contraindicated in the following cases:
Lactation
No gender/age discrimination
Alprostadil is contraindicated in lactation.
Pregnancy
No gender/age discrimination
Alprostadil is contraindicated in pregnancy.
Sickle cell anaemia or trait, multiple myeloma, leukaemia, angulation, cavernosal fibrosis, Peyronie's disease
No gender/age discrimination
Stenosis of urethra, severe hypospadias, curvature, balanitis, urethritis, angulation, cavernosal fibrosis, Peyronie's disease
No gender/age discrimination
Patients with anatomical deformation of the penis, such as stenosis of the distal urethra, severe hypospadias, severe curvature, balanitis, acute or chronic urethritis, angulation, cavernosal fibrosis or Peyronie’s disease.