Alprostadil

Chemical formula: C₂₀H₃₄O₅ Molecular mass: 354.487 g/mol PubChem compound: 5280723

Therapeutic indications

Alprostadil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Alprostadil is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Alprostadil may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1.25-40 μg

125-1000 μg

Temporary maintenance of patency of the ductus arteriosus until corrective or palliative surgery

Population group: only newborns (0 - 40 days old)

Alprostadil is indicated to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in infants who have congenital defects and who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atresia, tetralogy of Fallot, interruption of the aortic arch, co-arctation of the aorta, aortic stenosis, aortic atresia, mitral atresia, or transposition of the great vessels with or without other defects.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.05-0.1 μg/kg/min

Contraindications

Alprostadil is contraindicated in the following cases:

Pregnancy

Lactation

Stenosis of urethra, severe hypospadias, curvature, balanitis, urethritis, angulation, cavernosal fibrosis, Peyronie's disease

at least one of

Urethral stenosis

Hypospadias

Congenital lateral curvature of penis

Balanitis

Urethritis

Penis bent

Fibrosis of corpus cavernosum

Induratio penis plastica

Sickle cell anaemia or trait, multiple myeloma, leukaemia, angulation, cavernosal fibrosis, Peyronie's disease

at least one of

Sickle cell anemia

Thrombocytosis

Erythrocytosis

Multiple myeloma (clinical)

Leukaemia

Venous thrombosis

Thrombosis of penile vein

Recurrent priapism

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