Active ingredient description

Alvimopan is a selective antagonist of the cloned human μ-opioid receptor with a Ki of 0.4 nM (0.2 ng/mL) and no measurable opioid-agonist effects in standard pharmacologic assays. The dissociation of [3H]-alvimopan from the human μ-opioid receptor is slower than that of other opioid ligands, consistent with its higher affinity for the receptor. At concentrations of 1 to 10 µM, alvimopan demonstrated no activity at any of over 70 non-opioid receptors, enzymes, and ion channels.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
A Alimentary tract and metabolism → A06 Laxatives → A06A Laxatives → A06AH Peripheral opioid receptor antagonists
Discover more medicines within A06AH02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Structured Product Labeling (SPL/PLR)

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₅H₃₂N₂O₄
Molecular mass: 424.533 g/mol

External identifiers

CAS Substance: 156053-89-3
DrugBank Drug: DB06274
KEGG Drug: D02878
PubChem Compound: 5488548
RxNorm Ingredient: 480639
SNOMED-CT Concept: 437917007
Alvimopan (substance)
UNII Identifier: 677C126AET


Alvimopan is an active ingredient of these brands:

United States (US)

While we strive to include the brand names of medicines across all countries, our index remains incomplete. Therefore, it is possible that this medicine may also be marketed under different names in other countries.