Ambrisentan

Active ingredient description

Ambrisentan is an orally active, propanoic acid-class, ERA selective for the endothelin A (ETA) receptor. Endothelin plays a significant role in the pathophysiology of PAH.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
C02KX02
Ambrisentan
C Cardiovascular system → C02 Antihypertensives → C02K Other antihypertensives → C02KX Antihypertensives for pulmonary arterial hypertension
Discover more medicines within C02KX02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
VOLIBRIS Film-coated tablet
Summary of Product Characteristics (SPC)

Medicines

Ambrisentan is the active ingredient of these drugs:

Drug
Countries
BRIASETA

Estonia Ireland

LETAIRIS

United States

PULMORIS

Australia

VOLEBRIS

Mexico

VOLIBRIS

Australia Austria Brazil Canada Cyprus

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₂H₂₂N₂O₄
Molecular mass: 378.428 g/mol

External identifiers

CAS Substance: 177036-94-1
DrugBank Drug: DB06403
PubChem Compound: 6918493
RxNorm Ingredient: 358274
SNOMED-CT Concept: 428159003
Ambrisentan (substance)
UNII Identifier: HW6NV07QEC
AMBRISENTAN
 
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