Ambrisentan

Chemical formula: C₂₂H₂₂N₂O₄ Molecular mass: 378.428 g/mol PubChem compound: 6918493

Therapeutic indications

Ambrisentan is indicated for:

Pulmonary arterial hypertension (PAH) functional class (FC) II to III

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Ambrisentan is indicated for treatment of pulmonary arterial hypertension (PAH) in adult patients of WHO Functional Class (FC) II to III, including use in combination treatment. Efficacy has been shown in idiopathic PAH (IPAH) and in PAH associated with connective tissue disease.

Ambrisentan is indicated for treatment of PAH in adolescents and children (aged 8 to less than 18 years) of WHO Functional Class (FC) II to III including use in combination treatment. Efficacy has been shown in IPAH, familial, corrected congenital and in PAH associated with connective tissue disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg once daily and thereafter 5-10 mg once daily

2.5-5 mg initial once daily dose and 5-10 mg subsequent once daily dose titration based on body weight

Contraindications

Ambrisentan is contraindicated in the following cases:

Severe hepatic impairment with or without cirrhosis

Hepatic failure stage IV

Pregnancy

Lactation

Idiopathic pulmonary fibrosis

Usual interstitial pneumonia

Baseline values of hepatic aminotransferases >3xULN

at least one of

Serum glutamic oxaloacetic transaminase level raised
Alanine aminotransferase above reference range

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