Ambrisentan is indicated for:
Irrespective of gender only Adults (18 years old or older)
Ambrisentan is indicated for treatment of pulmonary arterial hypertension (PAH) in adult patients of WHO Functional Class (FC) II to III, including use in combination treatment. Efficacy has been shown in idiopathic PAH (IPAH) and in PAH associated with connective tissue disease.
For this indication, the medical literature mentions below treatments (click for details):
Active ingredient Ambrisentan is contraindicated in the following cases:
Ambrisentan is contraindicated in severe hepatic impairment.
Ambrisentan is contraindicated in idiopathic pulmonary fibrosis.
It is not known whether ambrisentan is excreted in human breast milk. The excretion of ambrisentan in milk has not been studied in animals. Therefore breast-feeding is contraindicated in patients taking ambrisentan.
Ambrisentan is contraindicated in pregnancy. Animal studies have shown that ambrisentan is teratogenic. There is no experience in humans. Women receiving ambrisentan must be advised of the risk of foetal harm and alternative therapy initiated if pregnancy occurs.