Amifostine

Active ingredient description

Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite. This metabolite is believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Amifostine
V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AF Detoxifying agents for antineoplastic treatment
Discover more medicines within V03AF05

Medicines

Amifostine is the active ingredient of these drugs:

Drug
Countries

Cyprus France South Africa United States

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

M487QF2F4V - AMIFOSTINE

CAS registry number

20537-88-6 - amifostine

SNOMED-CT

386923005 - Amifostine (substance)