Chemical formula: C₅H₁₅N₂O₃PS  Molecular mass: 214.223 g/mol  PubChem compound: 2141

Active ingredient description

Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite. This metabolite is believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
V03AF05 Amifostine V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AF Detoxifying agents for antineoplastic treatment
Discover more medicines within V03AF05

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 20537-88-6
DrugBank Drug: DB01143
PubChem Compound: 2141
RxNorm Ingredient: 4126
SNOMED-CT Concept: 386923005
Amifostine (substance)
UNII Identifier: M487QF2F4V


Amifostine is an active ingredient of these brands:

United States (US)

Cyprus (CY)

France (FR)

South Africa (ZA)

Turkey (TR)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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