Amiloride

Therapeutic indications

Amiloride is indicated for:

Hypertension

Population group: both men and women, only adults (18 years old or older)

Although amiloride Hydrochloride may be used alone, its principal indication is as concurrent therapy with thiazides or more potent diuretics to conserve potassium during periods of vigorous diuresis and during long term maintenance therapy. In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 2.5-5.0 mg given once a day

Congestive heart failure

Population group: both men and women, only adults (18 - 65 years old)

In congestive heart failure, amiloride hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 2.5-10.0 mg a day

Hepatic cirrhosis with ascites

Population group: both men and women, only adults (18 - 65 years old)

In hepatic cirrhosis with ascites, amiloride hydrochloride usually provides adequate diuresis, with diminished potassium loss and less risk of metabolic alkalosis, when used alone. It may be used with more potent diuretics when a greater diuresis is required while maintaining a more balanced serum electrolyte pattern.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 5-10 mg daily

Contraindications

Amiloride is contraindicated in the following cases:

Hyperkalaemia (plasma potassium over 5.5mmol/l)

Hyperkalaemia

Addison's disease

Addison's disease

Anuria

Anuria

Acute renal failure

Acute renal failure

Severe progressive renal disease

Renal failure

Diabetic nephropathy

Diabetic renal disease

Lithium

Lithium

Pregnancy

Pregnancy

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