Amiloride

Chemical formula: C₆H₈ClN₇O  Molecular mass: 229.627 g/mol  PubChem compound: 16231

Active ingredient description

Amiloride has mild diuretic and anti-hypertensive activity. It acts primarily in the distal tubule and does not require aldosterone for its action. Amiloride is a mild natriuretic which does not initiate a concomitant decrease in potassium levels.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C03DB01 Amiloride C Cardiovascular system → C03 Diuretics → C03D Potassium-sparing agents → C03DB Other potassium-sparing agents
Discover more medicines within C03DB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AMILORIDE ROSEMONT Oral solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 2016-88-8
CAS Substance: 2609-46-3
DrugBank Drug: DB00594
KEGG Drug: D07447
PubChem Compound: 16231
RxNorm Ingredient: 644
SNOMED-CT Concept: 387503008
Amiloride (substance)
UNII Identifier: 7DZO8EB0Z3
AMILORIDE

Medicines

Amiloride is an active ingredient of these brands:

Australia (AU)

  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

Austria (AT)

Brazil (BR)

  • (combination) ANCLORIC as AMILORIDE HYDROCHLORIDE
  • (combination) DIUPRESS as AMILORIDE HYDROCHLORIDE
  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

Canada (CA)

  • MIDAMOR as AMILORIDE HYDROCHLORIDE
  • (combination) AMILZIDE as AMILORIDE HYDROCHLORIDE
  • (combination) NOVAMILOR as AMILORIDE HYDROCHLORIDE

Cyprus (CY)

  • ALVERIX
  • (combination) FRUMIL as AMILORIDE HYDROCHLORIDE ANHYDROUS
  • (combination) MILOREX as AMILORIDE HYDROCHLORIDE

Ecuador (EC)

Estonia (EE)

  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

Finland (FI)

  • (combination) AMITRID as AMILORIDE HYDROCHLORIDE
  • (combination) DIURAMIN as AMILORIDE HYDROCHLORIDE

France (FR)

  • MODAMIDE as AMILORIDE HYDROCHLORIDE
  • (combination) LOGIRENE as AMILORIDE HYDROCHLORIDE
  • (combination) MODUCREN as AMILORIDE HYDROCHLORIDE

Germany (DE)

  • (combination) MODUCREN as AMILORIDE HYDROCHLORIDE
  • (combination) MODUCRIN as AMILORIDE HYDROCHLORIDE
  • (combination) TENSOFLUX as AMILORIDE HYDROCHLORIDE

Hong Kong (HK)

  • (combination) AMITHIAZIDE as AMILORIDE HYDROCHLORIDE
  • (combination) BILDURETIC as AMILORIDE HYDROCHLORIDE

Ireland (IE)

  • (combination) FRUMIL as AMILORIDE HYDROCHLORIDE ANHYDROUS

Israel (IL)

  • (combination) KALURIL as AMILORIDE HYDROCHLORIDE ANHYDROUS

Malta (MT)

  • (combination) MILOREX as AMILORIDE HYDROCHLORIDE

Mexico (MX)

  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

New Zealand (NZ)

  • (combination) FRUMIL as AMILORIDE HYDROCHLORIDE ANHYDROUS
  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

Nigeria (NG)

  • (combination) LEMURETIC as AMILORIDE HYDROCHLORIDE
  • (combination) ZORETIC as AMILORIDE HYDROCHLORIDE

Poland (PL)

  • (combination) TIALORID as AMILORIDE HYDROCHLORIDE

South Africa (ZA)

  • (combination) ACUMOD as AMILORIDE HYDROCHLORIDE
  • (combination) AMILORETIC as AMILORIDE HYDROCHLORIDE
  • (combination) BETARETIC as AMILORIDE HYDROCHLORIDE
  • (combination) DEZRETIC as AMILORIDE HYDROCHLORIDE
  • (combination) LORETIC as AMILORIDE HYDROCHLORIDE
  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE
  • (combination) SERVATRIN as AMILORIDE HYDROCHLORIDE

Spain (ES)

  • (combination) AMERIDE as AMILORIDE HYDROCHLORIDE
  • (combination) DIUZINE as AMILORIDE HYDROCHLORIDE
  • (combination) KALTEN as AMILORIDE HYDROCHLORIDE

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

  • (combination) FRUMIL as AMILORIDE HYDROCHLORIDE ANHYDROUS
  • (combination) MODURETIC as AMILORIDE HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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