Amitriptyline C₂₀H₂₃N
Also known as: Amitriptyline hydrochloride

Therapeutic indications

Amitriptyline is indicated for:

Major depressive disorder

Population group: both men and women, only adults (18 - 65 years old)

Amitriptyline is indicated for the treatment of major depressive disorder in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Major depressive disorder

Population group: both men and women, only elderly (65 years old or older)

Amitriptyline is indicated for the treatment of major depressive disorder.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Neuropathic pain, prophylactic treatment of chronic tension type headache and migraine

Population group: both men and women, only adults (18 - 65 years old)

Amitriptyline is indicated for:

  • the treatment of neuropathic pain in adults
  • the prophylactic treatment of chronic tension type headache (CTTH) in adults
  • the prophylactic treatment of migraine in adults

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Neuropathic pain, prophylactic treatment of chronic tension type headache and migraine

Population group: both men and women, only elderly (65 years old or older)

Amitriptyline is indicated for:

  • the treatment of neuropathic pain in adults
  • the prophylactic treatment of chronic tension type headache (CTTH) in adults
  • the prophylactic treatment of migraine in adults

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Nocturnal enuresis

Population group: both men and women, only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Nocturnal enuresis (finding)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Amitriptyline is contraindicated in the following cases:

Recent myocardial infarction

Recent myocardial infarction (situation)

Any degree of heart block or disorders of cardiac rhythm

Heart block (disorder)

Coronary artery insufficiency

at least one of
Coronary artery atheroma (disorder)
Stenotic coronary artery (finding)
Coronary artery stenosis (disorder)

Monoamine oxidase inhibitors (MAOIs)

MAO inhibitors

Severe liver disease

Hepatic failure stage IV

Pregnancy

Pregnancy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2018: AMITRIPTYLINE Film-coated tablet
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