Andexanet alfa

Active ingredient description

Andexanet alfa is a recombinant form of human FXa protein that has been modified to lack FXa enzymatic activity. The active site serine was substituted with alanine, rendering the molecule unable to cleave and activate prothrombin, and the gamma-carboxyglutamic acid (Gla) domain was removed to eliminate the ability of the protein to assemble into the prothrombinase complex, thus removing anyanti-coagulant effects.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Andexanet alfa
V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes
Discover more medicines within V03AB38

Medicines

Andexanet alfa is the active ingredient of these drugs:

Drug
Countries

United States

Austria Finland Ireland Lithuania Netherlands

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Structured Product Labeling (SPL/PLR)
US

Unique ingredient identifier (UNII)

BI009E452R - ANDEXANET ALFA

SNOMED-CT

783678000 - Andexanet alfa (substance)