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Andexanet alfa

Brand names: ANDEXXA


Andexanet alfa is a recombinant form of human FXa protein that has been modified to lack FXa enzymatic activity. The active site serine was substituted with alanine, rendering the molecule unable to cleave and activate prothrombin, and the gamma-carboxyglutamic acid (Gla) domain was removed to eliminate the ability of the protein to assemble into the prothrombinase complex, thus removing anyanti-coagulant effects.

ATC Classification

Andexanet alfa
V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes

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