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Andexanet alfa

Description

Andexanet alfa is a recombinant form of human FXa protein that has been modified to lack FXa enzymatic activity. The active site serine was substituted with alanine, rendering the molecule unable to cleave and activate prothrombin, and the gamma-carboxyglutamic acid (Gla) domain was removed to eliminate the ability of the protein to assemble into the prothrombinase complex, thus removing anyanti-coagulant effects.

ATC Classification

Code
Title
Category
V03AB38
Andexanet alfa
V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes

Trade names

Trade name
Countries

United States

Austria Netherlands United Kingdom

Product Monographs

Monograph
Type
Country
ANDEXXA Powder for solution for injection
MPI, US: SPL/PLR
US