Andexanet alfa

Active ingredient description

Andexanet alfa is a recombinant form of human FXa protein that has been modified to lack FXa enzymatic activity. The active site serine was substituted with alanine, rendering the molecule unable to cleave and activate prothrombin, and the gamma-carboxyglutamic acid (Gla) domain was removed to eliminate the ability of the protein to assemble into the prothrombinase complex, thus removing anyanti-coagulant effects.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes
Discover more medicines within V03AB38

Medicines

Andexanet alfa is the active ingredient of these drugs:

Drug
Countries

United States

Austria Estonia Finland Ireland Lithuania

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Structured Product Labeling (SPL/PLR)
US

External identifiers

CAS Substance: 1262449-58-0
DrugBank Drug: DB14562
RxNorm Ingredient: 2045114
SNOMED-CT Concept: 783678000
Andexanet alfa (substance)
UNII Identifier: BI009E452R
ANDEXANET ALFA