Andexanet alfa

Therapeutic indications

Andexanet alfa is indicated for:

Reversal of anticoagulation due to life-threatening or uncontrolled bleeding

Population group: only adults (18 years old or older)

For adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Andexanet alfa is contraindicated in the following cases:





Known allergic reaction to hamster proteins

Allergy to animal protein

Edoxaban or enoxaparin-reversal

at least one of
Administration of antidote
Drug action reversal
and additionally at least one of

Urgent surgery

Surgical procedure

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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