Angiotensin II

Chemical formula: C₅₀H₇₁N₁₃O₁₂  Molecular mass: 1,046.179 g/mol  PubChem compound: 172198

Active ingredient description

Angiotensin II raises blood pressure by vasoconstriction; increased aldosterone release via direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells which stimulates Ca2+/calmodulindependent phosphorylation of myosin and causes smooth muscle contraction.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01CX09 C Cardiovascular system → C01 Cardiac therapy → C01C Cardiac stimulants excl. cardiac glycosides → C01CX Other cardiac stimulants
Discover more medicines within C01CX09

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
GIAPREZA Concentrate for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC
GIAPREZA Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR

External identifiers

CAS Substance: 4474-91-3
DrugBank Drug: DB11842
PubChem Compound: 172198
RxNorm Ingredient: 1999003
SNOMED-CT Concept: 85267009
Angiotensin II (substance)
UNII Identifier: M089EFU921

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