Chemical formula: C₅₀H₇₁N₁₃O₁₂ Molecular mass: 1,046.179 g/mol PubChem compound: 172198
Angiotensin II raises blood pressure by vasoconstriction; increased aldosterone release via direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells which stimulates Ca2+/calmodulindependent phosphorylation of myosin and causes smooth muscle contraction.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| C01CX09 | C Cardiovascular system → C01 Cardiac therapy → C01C Cardiac stimulants excl. cardiac glycosides → C01CX Other cardiac stimulants | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| GIAPREZA Solution for injection | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| GIAPREZA Concentrate for solution for infusion | MPI, EU: SmPC | European Medicines Agency (EU) |
Angiotensin II is an active ingredient of these brands:
Austria (AT)Croatia (HR)Estonia (EE)Finland (FI)France (FR)Ireland (IE)Italy (IT)Lithuania (LT)Poland (PL)Romania (RO)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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