Chemical formula: C₅₀H₇₁N₁₃O₁₂ Molecular mass: 1,046.179 g/mol PubChem compound: 172198
Angiotensin II raises blood pressure by vasoconstriction; increased aldosterone release via direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells which stimulates Ca2+/calmodulindependent phosphorylation of myosin and causes smooth muscle contraction.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
|C Cardiovascular system → C01 Cardiac therapy → C01C Cardiac stimulants excl. cardiac glycosides → C01CX Other cardiac stimulants
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|GIAPREZA Concentrate for solution for infusion
|European Medicines Agency (EU)
|MPI, EU: SmPC
|GIAPREZA Solution for injection
|FDA, National Drug Code (US)
|MPI, US: SPL/PLR
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