Apixaban

Chemical formula: C₂₅H₂₅N₅O₄  Molecular mass: 459.497 g/mol  PubChem compound: 10182969

Active ingredient description

Apixaban is a potent, oral, reversible, direct and highly selective active site inhibitor of factor Xa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound factor Xa, and prothrombinase activity. By inhibiting factor Xa, apixaban prevents thrombin generation and thrombus development.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
B01AF02 B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AF Direct factor Xa inhibitors
Discover more medicines within B01AF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 ELIQUIS Granules in capsules for opening MPI, EU: SmPC European Medicines Agency (EU)
 ELIQUIS Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 503612-47-3
DrugBank Drug: DB06605
KEGG Drug: D03213
PubChem Compound: 10182969
RxNorm Ingredient: 1364430
SNOMED-CT Concept: 698090000
Apixaban (substance)
UNII Identifier: 3Z9Y7UWC1J
APIXABAN

Medicines

Apixaban is an active ingredient of these brands:

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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