Apixaban

Active ingredient description

Apixaban is a potent, oral, reversible, direct and highly selective active site inhibitor of factor Xa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound factor Xa, and prothrombinase activity. By inhibiting factor Xa, apixaban prevents thrombin generation and thrombus development.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AF Direct factor Xa inhibitors
Discover more medicines within B01AF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)

Medicines

Apixaban is the active ingredient of these drugs:

Drug
Countries

Ecuador Estonia Lithuania Poland Romania

Estonia Romania

Turkey

Estonia Romania

Ecuador

Australia Austria Brazil Canada Cyprus

Turkey

Tunisia

Ecuador

Ecuador

Turkey

Poland

Turkey

South Africa

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₅H₂₅N₅O₄
Molecular mass: 459.497 g/mol

External identifiers

CAS Substance: 503612-47-3
DrugBank Drug: DB06605
KEGG Drug: D03213
PubChem Compound: 10182969
RxNorm Ingredient: 1364430
SNOMED-CT Concept: 698090000
Apixaban (substance)
UNII Identifier: 3Z9Y7UWC1J
APIXABAN