Apixaban

Therapeutic indications

Apixaban is indicated for:

Prevention of venous thromboembolic events in total hip replacement surgery or total knee replacement surgery

Population group: both men and women, only adults (18 years old or older)

Prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective hip or knee replacement surgery.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 5 mg in 2 divided doses daily

Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF)

Population group: both men and women, only adults (18 years old or older)

Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA); age ≥75 years; hypertension; diabetes mellitus; symptomatic heart failure (NYHA Class ≥II).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 5-10 mg in 2 divided doses daily

Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)

Population group: both men and women, only adults (18 years old or older)

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Treatment 1: Oral - 5-20 mg in 2 divided doses daily

Contraindications

Apixaban is contraindicated in the following cases:

Anticoagulants

Antithrombotic agents

Active clinically significant bleeding

Bleeding

Lesion or condition, if considered a significant risk factor for major bleeding

at least one of
Gastrointestinal ulcer

Spinal injury

Traumatic brain injury

Intracranial hemorrhage

Operation on brain

Operative procedure on spinal structures

Esophageal varices

Aneurysm

Congenital vascular malformation

Severe hepatic impairment

Hepatic failure stage IV

Medication Recommendation

Receive personalized medication regimen for every patient case

Ask the Reasoner

Related medicines