Asenapine

The mechanism of action of asenapine is not fully understood. However, based on its receptor pharmacology, it is proposed that the efficacy of asenapine is mediated through a combination of antagonist activity at D₂ and 5-HT_2A receptors. Actions at other receptors e.g. 5-HT_1A, 5-HT_1B, 5-HT_2C, 5-HT₆, 5-HT₇, D₃, and a₂-adrenergic receptors, may also contribute to the clinical effects of asenapine.