Asparaginase

Also known as: Colaspase

Description

Asparaginase hydrolyses asparagine to aspartic acid and ammonia. In contrast to normal cells, lymphoblastic tumour cells have a very limited capacity for synthesising asparagine because of a significantly reduced expression of asparagine synthetase. Therefore, they require asparagine which diffuses from the extracellular environment. As a result of asparaginase-induced asparagine depletion in serum, protein synthesis in lymphoblastic tumour cells is disturbed while sparing most normal cells.

Medicine classification

ATC Code
Title
Class
Asparaginase
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents

Medicines

Drug
Countries

Austria Canada Netherlands United Kingdom

United States

Canada France

Hong Kong Singapore

Austria France Lithuania Netherlands United Kingdom

Product monographs

Unique Ingredient Identifier (UNII)

G4FQ3CKY5R - ASPARAGINASE

CAS Registry Number

9015-68-3 - Asparaginase

SNOMED-CT

371014004 - Asparaginase (substance)