Asparaginase Other names: Colaspase Crisantaspase

Chemical formula: C₁₃₇₇H₂₂₀₈N₃₈₂O₄₄₂S₁₇  PubChem compound: 5460875

Therapeutic indications

Asparaginase is indicated for:

Acute lymphoblastic leukaemia (ALL)

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Asparaginase is indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of acute lymphoblastic leukaemia (ALL) in adult and paediatric patients (1 month and older) who developed hypersensitivity or silent inactivation to E. coli-derived asparaginase.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Lymphoblastic lymphoma (LBL)

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Asparaginase is indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of lymphoblastic lymphoma (LBL) in adult and paediatric patients (1 month and older) who developed hypersensitivity or silent inactivation to E. coli-derived asparaginase.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Asparaginase is contraindicated in the following cases:

Pancreatitis

Pancreatitis

History of severe pancreatitis during previous asparaginase therapy

Pancreatitis

Severe thrombosis during previous asparaginase therapy

Thrombosis

Severe haemorrhagic events during previous asparaginase therapy

Bleeding

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