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Avanafil

Description

Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5. When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection.

ATC Classification

Code
Title
Category
G04BE10
Avanafil
G Genito urinary system and sex hormones → G04 Urologicals → G04B Other urologicals, incl. antispasmodics → G04BE Drugs used in erectile dysfunction

Trade names

Trade name
Countries

Australia Austria Cyprus France Netherlands

United States

Product Monographs

Monograph
Type
Country
SPEDRA Tablets
MPI, EU: SmPC