Avanafil C₂₃H₂₆ClN₇O₃

Therapeutic indications

Avanafil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Treatment of erectile dysfunction in adult men.

In order for avanafil to be effective, sexual stimulation is required.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Avanafil is contraindicated in the following cases:

Nitrates

at least one of
Organic nitrates
Glyceryl trinitrate
Isosorbide dinitrate
Amyl nitrite

Potent CYP3A4 inhibitors

Strong CYP3A4 inhibitors

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Guanylate cyclase stimulators

at least one of
Riociguat
Vericiguat

Pre-existing cardiovascular disease

at least one of
Myocardial infarction (disorder)
Cerebrovascular accident (disorder)
Cardiac arrhythmia (disorder)
Hypotension
Hypertensive disorder, systemic arterial (disorder)
Preinfarction syndrome (disorder)
Exercise-induced angina (disorder)
New York Heart Association Classification - Class II (finding)
New York Heart Association Classification - Class III (finding)
New York Heart Association Classification - Class IV (finding)

Loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION)

at least one of
Blind left eye (disorder)
Blind right eye (disorder)
and additionally
Non-arteritic ischemic optic neuropathy (disorder)

Hereditary degenerative retinal disorders

at least one of
Degeneration of retina (disorder)
Hereditary retinal dystrophy (disorder)

Get recommendations

Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

Ask the Reasoner

Related medicines

Summary of Product Characteristics (SPC) 2021: SPEDRA Tablet
< Previous: Overview
Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈