Avanafil

Chemical formula: C₂₃H₂₆ClN₇O₃  Molecular mass: 483.951 g/mol  PubChem compound: 9869929

Therapeutic indications

Avanafil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Treatment of erectile dysfunction in adult men.

In order for avanafil to be effective, sexual stimulation is required.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Avanafil is contraindicated in the following cases:

Nitrates

at least one of
Organic nitrates
Glyceryl trinitrate
Isosorbide dinitrate
Amyl nitrite

Potent CYP3A4 inhibitors

Strong CYP3A4 inhibitors

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Guanylate cyclase stimulators

at least one of
Riociguat
Vericiguat

Pre-existing cardiovascular disease

at least one of
Myocardial infarction
CVA - Cerebrovascular accident
Arrhythmia
Hypotension
Hypertension
Preinfarction syndrome
Exercise-induced angina
New York Heart Association Classification - Class II
New York Heart Association Classification - Class III
New York Heart Association Classification - Class IV

Loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION)

at least one of
Blind left eye
Loss of vision of right eye
and additionally Non-arteritic ischaemic optic neuropathy

Hereditary degenerative retinal disorders

at least one of
Degeneration of retina
Hereditary retinal dystrophy

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