Avanafil C₂₃H₂₆ClN₇O₃

Therapeutic indications

Avanafil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Treatment of erectile dysfunction in adult men.

In order for avanafil to be effective, sexual stimulation is required.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Avanafil is contraindicated in the following cases:


at least one of
Organic nitrates

Glyceryl trinitrate

Isosorbide dinitrate

Amyl nitrite

Potent CYP3A4 inhibitors

Strong CYP3A4 inhibitors

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Guanylate cyclase stimulators

at least one of


Pre-existing cardiovascular disease

at least one of
Myocardial infarction (disorder)

Cerebrovascular accident (disorder)

Cardiac arrhythmia (disorder)


Hypertensive disorder, systemic arterial (disorder)

Preinfarction syndrome (disorder)

Exercise-induced angina (disorder)

New York Heart Association Classification - Class II (finding)

New York Heart Association Classification - Class III (finding)

New York Heart Association Classification - Class IV (finding)

Loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION)

at least one of
Blind left eye (disorder)

Blind right eye (disorder)
and additionally
Non-arteritic ischemic optic neuropathy (disorder)

Hereditary degenerative retinal disorders

at least one of
Degeneration of retina (disorder)

Hereditary retinal dystrophy (disorder)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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