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Axitinib

Description

Axitinib is a potent and selective tyrosine kinase inhibitor of vascular endothelial growth factor receptors (VEGFR)-1, VEGFR-2 and VEGFR-3. These receptors are implicated in pathologic angiogenesis, tumour growth, and metastatic progression of cancer. Axitinib has been shown to potently inhibit VEGF-mediated endothelial cell proliferation and survival.

ATC Classification

Code
Title
Category
L01EK01
Axitinib
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EK Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors

Trade names

Trade name
Countries
INLYTA

Australia Austria Cyprus Netherlands Singapore

Product Monographs

Monograph
Type
Country
INLYTA Film-coated tablet
MPI, EU: SmPC

2D Molecule Structure

Unique Ingredient Identifier (UNII)

C9LVQ0YUXG - AXITINIB

CAS Registry Number

319460-85-0 - axitinib

SNOMED-CT

427882000 - Axitinib (substance)

 
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