Azacitidine Other names: Azacytidine

Chemical formula: C₈H₁₂N₄O₅  Molecular mass: 244.205 g/mol  PubChem compound: 9444

Therapeutic indications

Azacitidine is indicated for:

Myelodysplastic syndromes, chronic myelomonocytic leukaemia, acute myeloid leukaemia

Population group: only adults (18 years old or older)

Azacitidine is indicated for the treatment of adult patients who are not eligible for haematopoietic stem cell transplantation (HSCT) with:

  • intermediate-2 and high-risk myelodysplastic syndromes (MDS) according to the International Prognostic Scoring System (IPSS),
  • chronic myelomonocytic leukaemia (CMML) with 10-29% marrow blasts without myeloproliferative disorder,
  • acute myeloid leukaemia (AML) with 20-30% blasts and multi-lineage dysplasia, according to World Health Organisation (WHO) classification,
  • AML with >30% marrow blasts according to the WHO classification.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Azacitidine is contraindicated in the following cases:

Lactation

Lactation

Advanced malignant hepatic tumours

Malignant neoplasm of liver

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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