Baloxavir marboxil

Chemical formula: C₂₇H₂₃F₂N₃O₇S  Molecular mass: 571.55 g/mol 

Active ingredient description

Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza activity. Baloxavir acts on the cap-dependent endonuclease (CEN), an influenza virus-specific enzyme in the polymerase acidic (PA) subunit of the viral RNA polymerase complex and thereby inhibits the transcription of influenza virus genomes resulting in inhibition of influenza virus replication.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
J05AX25 J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AX Other antivirals
Discover more medicines within J05AX25

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 XOFLUZA Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)
 XOFLUZA Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1985606-14-1
DrugBank Drug: DB13997
KEGG Drug: D11021
RxNorm Ingredient: 2099995
SNOMED-CT Concept: 782500006
Baloxavir marboxil (substance)
UNII Identifier: 505CXM6OHG
BALOXAVIR MARBOXIL

Medicines

Baloxavir marboxil is an active ingredient of these brands:

Austria (AT)

Croatia (HR)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Japan (JP)

Lithuania (LT)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Turkey (TR)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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