Bempedoic acid

Chemical formula: C₁₉H₃₆O₅  Molecular mass: 344.492 g/mol  PubChem compound: 10472693

Therapeutic indications

Bempedoic acid is indicated for:

Primary hypercholesterolaemia

Population group: only adults (18 years old or older)

Bempedoic acid is indicated in adults with primary hypercholesterolaemia (heterozygous familial and nonfamilial) as an adjunct to diet:

  • in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin or,
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Mixed dyslipidaemia

Population group: only adults (18 years old or older)

Bempedoic acid is indicated in adults with mixed dyslipidaemia, as an adjunct to diet:

  • in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin or,
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Established atherosclerotic cardiovascular disease

Population group: only adults (18 years old or older)

Bempedoic acid is indicated in adults with established or at high risk for atherosclerotic cardiovascular disease to reduce cardiovascular risk by lowering LDL-C levels, as an adjunct to correction of other risk factors:

  • in patients on a maximum tolerated dose of a statin with or without ezetimibe or,
  • alone or in combination with ezetimibe in patients who are statin-intolerant, or for whom a statin is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Bempedoic acid is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Concomitant use with simvastatin >40 mg daily

Simvastatin

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