Chemical formula: C₃₀H₅₀O₂ Molecular mass: 442.381 g/mol
Betulin accelerated re-epithelialization in an in vitro wound scratch assay using human primary keratinocytes at the dosage of 1 μg/ml, and in a porcine ex vivo wound healing model at the dosage of 10 µg/ml. The precise mechanism of action of the active substance in wound healing in humans is not known.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D03AX13 | D Dermatologicals → D03 Preparations for treatment of wounds and ulcers → D03A Cicatrizants → D03AX Other cicatrizants | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| EPISALVAN Gel | European Medicines Agency (EU) | MPI, EU: SmPC |
Betulin is an active ingredient of these brands:
Austria (AT)Croatia (HR)France (FR)Ireland (IE)Italy (IT)Lithuania (LT)Poland (PL)
Romania (RO)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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