Binimetinib

Chemical formula: C₁₇H₁₅BrF₂N₄O₃  Molecular mass: 441.233 g/mol  PubChem compound: 10288191

Active ingredient description

Binimetinib is an ATP-uncompetitive, reversible inhibitor of the kinase activity of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. Binimetinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
L01EE03 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EE Mitogen-activated protein kinase (MEK) inhibitors
Discover more medicines within L01EE03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 MEKTOVI Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 606143-89-9
DrugBank Drug: DB11967
PubChem Compound: 10288191
RxNorm Ingredient: 2049122
SNOMED-CT Concept: 772195005
Binimetinib (substance)
UNII Identifier: 181R97MR71
BINIMETINIB

Medicines

Binimetinib is an active ingredient of these brands:

Australia (AU)

Austria (AT)

Croatia (HR)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Netherlands (NL)

Nigeria (NG)

Poland (PL)

Romania (RO)

Spain (ES)

United Kingdom (UK)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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