Chemical formula: C₂₂H₁₉NO₄ Molecular mass: 361.391 g/mol PubChem compound: 2391
Bisacodyl interacts in the following cases:
The concomitant use of antacids and milk products may reduce the resistance of the coating of the tablets and result in dyspepsia and gastric irritation.
The concomitant use of other laxatives may enhance the gastrointestinal side effects of bisacodyl.
Electrolyte imbalance may lead to increased sensitivity to cardiac glycosides.
The concomitant use of diuretics or adreno-corticosteroids may increase the risk of electrolyte imbalance if excessive doses of bisacodyl are taken.
There are no adequate and well-controlled studies in pregnant women. Long experience has shown no evidence of undesirable or damaging effects during pregnancy.
Nevertheless, as with all medicines, bisacodyl should not be taken in pregnancy, especially the first trimester, unless the expected benefit is thought to outweigh any possible risk.
Clinical data show that neither the active moiety of bisacodyl (BHPM or bis- (p-hydroxyphenyl)-pyridyl-2-methane) nor its glucuronides are excreted into the milk of healthy lactating females.
Nevertheless, as with all medicines, bisacodyl should not be taken during breast feeding unless the expected benefit is thought to outweigh any possible risk.
No studies on the effect on human fertility have been conducted.
No studies on the effects of bisacodyl on the ability to drive and use machines have been performed.
However, patients should be advised that due to a vasovagal response (e.g. to abdominal spasm) they may experience dizziness and/or syncope. If patients experience abdominal spasm they should avoid potentially hazardous tasks such as driving or operating machinery.
The most commonly reported adverse reactions during treatment are abdominal pain and diarrhoea.
Adverse events have been ranked under headings of frequency using the following convention: Very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (<1/10000).
Rare: anaphylactic reactions, angioedema, hypersensitivity.
Rare: dehydration.
Uncommon: dizziness.
__Rare: Syncope. Dizziness and syncope occurring after taking bisacodyl appear to be consistent with a vasovagal response (e.g. to abdominal spasm, defaecation).
Uncommon: haematochezia (blood in stool), vomiting, abdominal discomfort, anorectal discomfort.
Common: abdominal cramps, abdominal pain, diarrhoea and nausea.
Rare: colitis including ischaemic colitis.
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