Buprenorphine Other names: Buprenorphine hydrochloride
Chemical formula: C₂₉H₄₁NO₄ Molecular mass: 467.64 g/mol PubChem compound: 644073
Active ingredient description
Buprenorphine is an opioid partial agonist/antagonist which attaches itself to the μ (mu) and κ (kappa) receptors of the brain. Its activity in opioid maintenance treatment is attributed to its slowly reversible link with the μ receptors which, over a prolonged period, minimises the need of illicit opioids for patients with opioid dependence.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| N02AE01 | Buprenorphine | N Nervous system → N02 Analgesics → N02A Opioids → N02AE Oripavine derivatives |
| N07BC01 | Buprenorphine | N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BC Drugs used in opioid dependence |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| BUPRENORPHINE Sublingual tablet | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| RELETRANS Transdermal patch | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| BUTRANS Transdermal system | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| SUBLOCADE Solution for injection | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| BUVIDAL Prolonged-release solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| SIXMO Implant | MPI, EU: SmPC | European Medicines Agency (EU) |
Medicines
Buprenorphine is an active ingredient of these brands:
Australia (AU)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Italy (IT)
Japan (JP)Lithuania (LT)
Malta (MT)Mexico (MX)Netherlands (NL)
New Zealand (NZ)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)
United Kingdom (UK)
United States (US)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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