Chemical formula: C₁₃H₁₈ClNO Molecular mass: 239.741 g/mol PubChem compound: 444
Bupropion is a selective inhibitor of the neuronal re-uptake of catecholamines (noradrenaline and dopamine) with minimal effect on the re-uptake of indolamines (serotonin) and does not inhibit either monoamine oxidase. The mechanism by which bupropion enhances the ability of patients to abstain from smoking is unknown. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N06AX12 | Bupropion | N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AX Other antidepressants |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| WELLBUTRIN XL Extended-release tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| WELLBUTRIN SR Sustained‑release tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| ZYBAN Prolonged release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Bupropion is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
France (FR)
Germany (DE)
Hong Kong (HK)
Israel (IL)
Italy (IT)
Malta (MT)
Mexico (MX)
Netherlands (NL)
Poland (PL)Romania (RO)Singapore (SG)
South Africa (ZA)Spain (ES)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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