Levoleucovorin Other names: Calcium levofolinate Levofolinic acid Levoleucovorin calcium

Chemical formula: C₂₀H₂₃N₇O₇ Molecular mass: 473.439 g/mol PubChem compound: 135398559

Therapeutic indications

Levoleucovorin is indicated for:

Calcium levofolinate rescue

Population group: only adults (18 - 65 years old)

Calcium levofolinate is used to diminish the toxicity and counteract the action of folic acid antagonists such as methotrexate in cytotoxic therapy. This procedure is known as calcium levofolinate rescue.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3-6 mg/m² 12–24 hours after the beginning of methotrexate infusion and thereafter given every 6 hours throughout a period of 72 hours

Contraindications

Levoleucovorin is contraindicated in the following cases:

Megaloblastic anaemias due to vitamin B₁₂ deficiency

Megaloblastic anemia due to vitamin B>12< deficiency

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