Carmustine Other names: Bischlorethylnitrosourea Bischlorethylnitrosurea BCNU

Chemical formula: C₅H₉Cl₂N₃O₂  Molecular mass: 214.05 g/mol  PubChem compound: 2578

Active ingredient description

Carmustine is a cell-cycle phase nonspecific antineoplastic agent of the nitrosourea type. As an alkylating agent, it can alkylate reactive sites on nucleoproteins, thus interfering with DNA and RNA synthesis and DNA repair. In addition, carmustine is known to carbamoylate lysine residues on proteins causing irreversible inactivation of enzymes including glutathione reductase.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01AD01 Carmustine L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AD Nitrosoureas
Discover more medicines within L01AD01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CARMUSTINE OBVIUS Powder and solvent for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC
GLIADEL Implant Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 154-93-8
DrugBank Drug: DB00262
KEGG Drug: D00254
PubChem Compound: 2578
RxNorm Ingredient: 2105
SNOMED-CT Concept: 387281007
Carmustine (substance)
UNII Identifier: U68WG3173Y
CARMUSTINE

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