Carmustine Other names: Bischlorethylnitrosourea Bischlorethylnitrosurea BCNU

Chemical formula: C₅H₉Cl₂N₃O₂  Molecular mass: 214.05 g/mol  PubChem compound: 2578

Therapeutic indications

Carmustine is indicated for:

Glioblastoma, brain-stem gliomas, medulloblastoma, astrocytoma, ependymoma, brain metastases

Population group: only adults (18 years old or older)

Carmustine is effective in brain tumours (glioblastoma, Brain-stem gliomas, medulloblastoma, astrocytoma and ependymoma), brain metastases as a single agent or in combination with other antineoplastic agents and/or other therapeutic measures (radiotherapy, surgery).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-Hodgkin's lymphoma, Hodgkin's disease

Population group: only adults (18 years old or older)

Carmustine is effective in secondary therapy in non-Hodgkin’s lymphoma and Hodgkin’s disease as a single agent or in combination with other antineoplastic agents and/or other therapeutic measures (radiotherapy, surgery).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Carmustine is contraindicated in the following cases:

Lactation

Lactation

Severe bone marrow depression

Bone marrow depression

Severe (end-stage) renal impairment

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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