Chemical formula: C₁₈H₁₉N₃O₅S Molecular mass: 389.426 g/mol PubChem compound: 5281006
Cefprozil interacts in the following cases:
For those with creatinine clearance values ≤30 ml/min, 50% of the standard dose should be given at the standard dosing interval. Cefprozil is in part removed by hemodialysis; therefore, cefprozil should be administered after the completion of hemodialysis.
Cephalosporins, including cefprozil, should be given with caution to patients receiving concurrent treatment with potent diuretics since these agents are suspected of adversely affecting renal function.
Concomitant administration of cefprozil and aminoglycoside antibiotics causes nephrotoxicity.
Coadministration of cefprozil with probenecid doubles the area under the curve (AUC) of cefprozil.
Safety of use in pregnancy has not been established.
Safety of use in lactation has not been established.
Cefprozil may cause dizziness which may affect ability to drive or use machinery. These activities should not be performed until the influence of cefprozil on the individual has been determined.
Frequent: Eosinophilia.
Less frequent: Neutropenia, thrombocytopenia. Prolonged PT/INR has been observed.
Less frequent: Anaphylaxis, fever, serum sickness and pseudomembranous colitis.
Frequency unknown: Angioedema
The following side effects have been reported and frequencies are unknown: Dizziness, hyperactivity, headache, nervousness, insomnia, confusion and somnolence.
Frequent: Nausea, vomiting, diarrhoea and abdominal pain.
Less frequent: Cholestatic jaundice.
The following side effects have been reported and frequencies are unknown: Elevations of AST, ALT, alkaline phosphatase, bilirubin values.
Less frequent: Erythema multiforme, Stevens-Johnson syndrome, superinfection, rash, urticaria.
The following side effects have been reported and frequencies are unknown: Elevations in blood urea and serum creatinine.
Less frequent: General pruritus and vaginitis.
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