Ciclesonide

Chemical formula: C₃₂H₄₄O₇  Molecular mass: 540.697 g/mol  PubChem compound: 6918155

Active ingredient description

Ciclesonide exhibits low binding affinity to the glucocorticoid-receptor. Once orally inhaled, ciclesonide is enzymatically converted in the lungs to the principal metabolite (C21-des-methylpropionyl-ciclesonide) which has a pronounced anti-inflammatory activity and is thus considered as the active metabolite.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R01AD13 R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AD Corticosteroids
Discover more medicines within R01AD13
R03BA08 Ciclesonide R Respiratory system → R03 Drugs for obstructive airway diseases → R03B Other drugs for obstructive airway diseases, inhalants → R03BA Glucocorticoids
Discover more medicines within R03BA08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
OMNARIS Nasal spray FDA, National Drug Code (US) MPI, US: SPL/PLR
ALVESCO 80 Pressurised inhalation, solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 126544-47-6
DrugBank Drug: DB01410
KEGG Drug: D01703
PubChem Compound: 6918155
RxNorm Ingredient: 274964
SNOMED-CT Concept: 417420004
Ciclesonide (substance)
UNII Identifier: S59502J185
CICLESONIDE

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