Cinnarizine

Interactions

Active ingredient Cinnarizine interacts in the following cases:

Hepatic dysfunction, renal dysfunction

There have been no specific studies in hepatic or renal dysfunction. Cinnarizine should be used with care in patients with hepatic or renal insufficiency.

Alcohol, CNS depressants, tricyclic antidepressants

Concurrent use of alcohol, CNS depressants or tricyclic antidepressants may potentiate the sedative effects of either these drugs or of cinnarizine.

Effects on ability to drive and use machines

Cinnarizine may cause drowsiness, especially at the start of treatment; patients affected in this way should not drive or operate machinery.

Lactation

There are no data on the excretion of cinnarizine in human breast milk. Use of cinnarizine is not recommended in nursing mothers.

Pregnancy

The safety of cinnarizine in human pregnancy has not been established although studies in animals have not demonstrated teratogenic effects. As with other drugs it is not advisable to administer cinnarizine in pregnancy.

Porphyria

Use of cinnarizine should be avoided in porphyria.

Parkinson's disease

In patients with Parkinson’s Disease, cinnarizine should only be given if the advantages outweigh the possible risk of aggravating this disease.

Pregnancy

The safety of cinnarizine in human pregnancy has not been established although studies in animals have not demonstrated teratogenic effects. As with other drugs it is not advisable to administer cinnarizine in pregnancy.

Nursing mothers

There are no data on the excretion of cinnarizine in human breast milk. Use of cinnarizine is not recommended in nursing mothers.

Effects on ability to drive and use machines

Cinnarizine may cause drowsiness, especially at the start of treatment; patients affected in this way should not drive or operate machinery.

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