Cis-Diaminedichloroplatinum Other names: Cisplatin Platinum Ammine Chloride Trans-Diaminedichloroplatinum

Chemical formula: Cl₂H₆N₂Pt Molecular mass: 300.05 g/mol PubChem compound: 2767

Therapeutic indications

Cis-Diaminedichloroplatinum is indicated for:

Head and neck squamous-cell epithelioma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

To be used as mono-therapy, or as part of an existing chemotherapy for advanced or metastatic tumours of head and neck squamous-cell epithelioma (palliative therapy).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-120 mg/m² once every 3-4 weeks

15-20 mg/m² once for 5 days every 3-4 weeks

Testicular carcinoma

Population group: men, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

To be used as mono-therapy, or as part of an existing chemotherapy for advanced or metastatic tumours of testicular carcinoma (palliative and curative poly-chemotherapy).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-120 mg/m² once every 3-4 weeks

15-20 mg/m² once for 5 days every 3-4 weeks

Ovary carcinoma

Population group: women, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

To be used as mono-therapy, or as part of an existing chemotherapy for advanced or metastatic tumours of ovary carcinoma (stages III and IV).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-120 mg/m² once every 3-4 weeks

15-20 mg/m² once for 5 days every 3-4 weeks

Small cell carcinoma of lung

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

In the treatment of small cell lung carcinoma.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-120 mg/m² once every 3-4 weeks

15-20 mg/m² once for 5 days every 3-4 weeks

Non-small cell lung cancer

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

In the treatment of advanced non-small cell lung carcinoma.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-120 mg/m² once every 3-4 weeks

15-20 mg/m² once for 5 days every 3-4 weeks

Contraindications

Cis-Diaminedichloroplatinum is contraindicated in the following cases:

Dehydrated condition

Dehydration

Myelosuppression

Myelosuppression

Pregnancy

Pregnancy

Lactation

Lactation

Renal impairment

Renal failure

Hearing impairment

Hearing loss

Yellow fever vaccine

Yellow fever vaccines

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