Collagenase Other names: Collagenase clostridium histolyticum Clostridiopeptidase

PubChem compound: 44384985

Active ingredient description

Collagenases are proteinases that hydrolyze collagen under physiological conditions. Collagenase clostridium histolyticum is comprised of a mixture of Class I (AUX-I) and Class II (AUX-II) clostridial collagenases in a defined mass ratio. Both collagenases effectively cleave interstitial collagen but at different sites on the molecule; additionally, they prefer different conformations (triple helical versus denatured or cleaved).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D03BA02 Clostridiopeptidase D Dermatologicals → D03 Preparations for treatment of wounds and ulcers → D03B Enzymes → D03BA Proteolytic enzymes
Discover more medicines within D03BA02
M09AB02 M Musculo-skeletal system → M09 Other drugs for disorders of the musculo-skeletal system → M09A Other drugs for disorders of the musculo-skeletal system → M09AB Enzymes
Discover more medicines within M09AB02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
XIAPEX Powder and solvent for solution for injection European Medicines Agency (EU) MPI, EU: SmPC
COLLAGENASE SANTYL Ointment FDA, National Drug Code (US) MPI, US: SPL/Old

External identifiers

CAS Substance: 9001-12-1
DrugBank Drug: DB00048
KEGG Drug: D09596
PubChem Compound: 44384985
RxNorm Ingredient: 898492
SNOMED-CT Concept: 56355009
Clostridium histolyticum collagenase (substance)
SNOMED-CT Concept: 772213007
Collagenase (substance)
UNII Identifier: 9X7O8V25IT
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

Medicines

Collagenase is an active ingredient of these brands:

United States (US)

Austria (AT)

Brazil (BR)

Canada (CA)

Ecuador (EC)

Estonia (EE)

Hong Kong (HK)

Ireland (IE)

Lithuania (LT)

Mexico (MX)

  • (combination) ULCODERMA as Clostridiopeptidase A

Netherlands (NL)

Poland (PL)

Singapore (SG)

Spain (ES)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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