Cytarabine

Chemical formula: C₉H₁₃N₃O₅  Molecular mass: 243.217 g/mol  PubChem compound: 6253

Therapeutic indications

Cytarabine is indicated for:

Acute myeloid leukaemia, acute non-lymphoblastic leukaemia, acute lymphoblastic leukaemia, acute lymphocytic leukaemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Cytarabine may be used alone or in combination with other antineoplastic agents. It is indicated alone or in combination for induction of remission and/or maintainance in patients with acute myeloid leukaemia, acute non-lymphoblastic leukaemias, acute lymphoblastic leukaemias, acute lymphocytic leukaemia, and blast crises of chronic myeloid leukaemia. Clinicians should refer to the current literature on combination therapy before initiating treatment.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Leukaemic meningitis

Population group: only adults (18 years old or older)

Meningeal leukemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Cytarabine is contraindicated in the following cases:

Anaemia, leucopenia, thrombocytopenia

at least one of
Anemia and additionally not Anemia in neoplastic disease

Leukopenia
Thrombocytopenic disorder

Pregnancy

Pregnancy

Degenerative and toxic encephalopathies

at least one of
Degenerative brain disorder
Toxic and/or metabolic encephalopathy

Live-attenuated vaccines

Live organism vaccines

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2021: CYTARABINE Solution for injection
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