Chemical formula: C₂₀H₁₉N₅ Molecular mass: 329.398 g/mol PubChem compound: 214347
Dapivirine is an NNRTI with potent antiviral activity against HIV-1. It prevents viral replication by binding directly to HIV-1 reverse transcriptase (RT) and blocking its activity. Dapivirine binding is non-competitive against both the RNA template and the nucleotide substrate.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| G01AX17 | G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AX Other antiinfectives and antiseptics | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DAPIRING Vaginal delivery system | Health Products Regulatory Authority (ZA) | MPI, Generic |
Dapivirine is an active ingredient of these brands:
South Africa (ZA)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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