Daprodustat

Chemical formula: C₁₉H₂₇N₃O₆  Molecular mass: 393.19 g/mol  PubChem compound: 91617630

Active ingredient description

Daprodustat is indicated for the treatment of anemia due to chronic kidney disease. Daprodustat is a reversible inhibitor of HIF-PH1, PH2 and PH3 (IC50 in the low nM range). This activity results in the stabilization and nuclear accumulation of HIF-1α and HIF-2α transcription factors, leading to increased transcription of the HIF-responsive genes, including erythropoietin.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B03XA07 B Blood and blood forming organs → B03 Antianemic preparations → B03X Other antianemic preparations → B03XA Other antianemic preparations
Discover more medicines within B03XA07

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
JESDUVROQ Film coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 960539-70-2
DrugBank Drug: DB11682
KEGG Drug: D10874
PubChem Compound: 91617630
RxNorm Ingredient: 2628210
UNII Identifier: JVR38ZM64B
DAPRODUSTAT

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