Digoxin

Chemical formula: C₄₁H₆₄O₁₄  Molecular mass: 780.939 g/mol  PubChem compound: 2724385

Active ingredient description

Digoxin increases contractility of the myocardium by direct activity. The primary action of digoxin is specifically to inhibit adenosine triphosphatase, and thus sodium-potassium (Na+ - K+) exchange activity, the altered ionic distribution across the membrane resulting in an augmented calcium ion influx and thus an increase in the availability of calcium at the time of excitation-contraction coupling. The potency of digoxin may therefore appear considerably enhanced when the extracellular potassium concentration is low, with hyperkalaemia having the opposite effect.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01AA05 Digoxin C Cardiovascular system → C01 Cardiac therapy → C01A Cardiac glycosides → C01AA Digitalis glycosides
Discover more medicines within C01AA05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
DIGOXIN Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
LANOXIN Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR
DIGOXIN Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
LANOXIN Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 20830-75-5
DrugBank Drug: DB00390
KEGG Drug: D00298
PubChem Compound: 2724385
RxNorm Ingredient: 3407
SNOMED-CT Concept: 387461009
Digoxin (substance)
UNII Identifier: 73K4184T59
DIGOXIN

Medicines

Digoxin is an active ingredient of these brands:

United States (US)

Australia (AU)

Brazil (BR)

Canada (CA)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Singapore (SG)

South Africa (ZA)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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